ESPE Yearbook of Paediatric Endocrinology

Science. 2021 Aug 13;373(6556):808–812 doi: 10.1126/science.abe5017Brief summary: This study compiled a large database of doubly labeled water measurements on a large (N=6421) and diverse (N=29 countries) population aged between 8 days and 95 years to provide the first comprehensive study of total energy expenditure (TEE) and basal metabolic rate (BMR) over the human li...

To read the full abstract: J Hepatol. 2019;71(4):802–10. doi: 10.1016/j.jhep.2019.06.023Short summary: Prediabetes is highly prevalent in Caucasian children and adolescents with well-characterized, biopsy-proven non-alcoholic fatty liver disease (NAFLD).Comment: NAFLD is considered the liver presentation of the metabolic syndrome. NAFLD enco...

To read the full abstract: Cell Metab. 2020;31(1):92–104 e5. doi: 10.1016/j.cmet.2019.11.004Short summary: Ten-hour time-restricted eating (TRE) for 12 weeks in adults with metabolic syndrome treated with standard medical care resulted in weight loss, decreased waist circumference, and lower blood pressure and levels of cardiovascular disease-promoting lipids.<p class=...

To read the full abstract: Cell. 2019;179(6):1276–88 e14. doi: 10.1016/j.cell.2019.10.034Short summary: Deficiency in the orphan G protein coupled receptor 146 (GPR146) decreases blood lipid levels and protects against atherosclerosis in mice, independent of LDL receptor activity.Comment: Monogenic hypercholesterolemia is a heterogeneous gro...

To read the full abstract: N Engl J Med. 2019;381(16):1547–56. doi: 10.1056/NEJMoa1816454Short summary: Twenty years of treatment of statin therapy in children with Familial Hypercholesterolemia (FH) slowed the progression of carotid intima–media thickness and reduced the risk of cardiovascular disease in adulthood. By age 39 years, the cumulative incidence of cardiovascul...

To read the full abstract: Cochrane Database Syst Rev. 2019;2019(11). doi: 10.1002/14651858.CD006401.pub5Short summary: This systematic review shows that statin treatment is an effective lipid-lowering therapy in children with Familial Hypercholesterolemia (FH). Few or no safety issues were identified.Comment: Cochrane is an international cha...

To read the full abstract: Cell. 2020. doi: 10.1016/j.cell.2020.04.034Short summary: In this study, rather than focusing on genes associated with obesity, the authors studied genetic variants associated with thinness (BMI <6th percentile for age). In a genome-wide association study from the Estonian Biobank, 881 people were classified as thin, and 3173 individuals with norm...

To read the full abstract: Diabetes Care. 2020. doi: 10.2337/dc20-0723Short summary: In this observational cohort of hospitalised COVID-19 patients in Italy, patients who had hyperglycaemia, with or without diabetes, were at higher risk for severe COVID disease than normoglycaemic patients. Insulin infusion was effective for achieving glycaemic targets and reducing mortality in patients...

To read the full abstract: Arch Med Sci. 2020;16(1):34–41. doi: 10.5114/aoms.2019.88406Short summary: Alarming numbers are reported here on the high prevalence of T2DM in children and adolescents in Hungary. In this nationwide population-based study, the prevalence of T2DM in children aged 0–18 years rose between 2001 and 2006 from 20/100 000 to 36/100 000 and decreased ...

To read the full abstract: Pediatr Diabetes. 2020;21(2):224–32. doi: 10.1111/pedi.12976Short summary: This high-quality, longitudinal lifestyle intervention, with ample funding, had little effect on improving health behaviour profiles of adolescents with T2DM.Comment: The first sweeping recommendation for adolescents with obesity, and certainly for ...